The purpose of ss this study was to observe the effect of TGF-Rl on the regeneration of bone in guided bore regeneration. Four adult dogs aged 12 to 24 months were used in this study. Experimental bone defects were created surgically with surgical bur and chisel on the 3th. premolars. In experimental group; bone defect were grafted with DFDB and TGF-R1. In control groups, bone defects were grafted with only Dl-.DB. At 1, 2, 3 and 4 weeks, dogs were serially sacrificed and specimens were prepared with Hematoxylin-Eosin stain and Goldner`s stain for light microscopic evaluation.
The results of this study were as follows
1. The infiltration of inflammatory cells was prominent in control groups at 1, 2 and 3 weeks.
2. The lining of osteoblast was observed at 2 weeks in control group, but at 1 week in experimental group.
3. In both groups, osteoid was formed at 2 weeks. In control groups, osteoid was fromed on only bone surface. but in experimental groups, osteoid were formed on both bone & DFDB surfaces.
4. In only experimental groups, The fusion of new bone & DFDB was only observed at 3 weeks. and the fusion of new bone & DFDG was more prominent at 4 weeks. But in control groups, No fusion of new bone & DFDB was oberved at 3 and 4weeks
From the above result, the TGF-01 was effective in bone formation and increased inductive effect of DFDB guided bone regeneration technique. Inductive effect of DFDB was increased with TGF-131.
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